Immunosuppressive:
Immunosuppression (English: immunosuppression) refers to the suppression of the immune response. A weakened immune system is prone to infections such as bacteria, viruses, fungi, and even tumors.
However, abnormal immunity can also cause damage to the body. For example, many autoimmune diseases are caused by abnormal expression of autoimmunity, and normal tissues of the body are regarded as the target of attack, causing damage to the body.
Concept:
The immune system includes various cells, tissues and organs involved in the immune response, such as the thymus, lymph nodes, spleen, tonsils, and lymphocytes and plasma cells that are distributed throughout body fluids and tissues. These components and their normal functions are the basic guarantee of the body's immune function. Any defect will lead to immune dysfunction, loss of resistance to infection or the formation of immune diseases.
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Basic process:
The immune response process involves a variety of interactions between immune cells, such as T-M, T-B, Th-Ts, and Ts-Tc, among which Ts and Th play a key role in immune regulation. Activated Th cells help B cells produce antibodies, help Tc cells kill target cells, induce M, and exhibit delayed-type hypersensitivity. Ts cells in turn inhibit the functions of Th, Tc, B cells and M. Similarly, B cells and M can also promote and inhibit T cells and each other through various mechanisms.
Immunosuppressant:
(1) Glucocorticoids, such as cortisone, prednisone, prednisolone, etc.;
(2) Microbial metabolites, such as cyclosporin and tacrolimus, etc.;
(3) Antimetabolites, such as azathioprine and 6-mercaptopurine;
(4) Polyclonal and monoclonal anti-lymphocyte antibodies, such as anti-lymphocyte globulin and OKT3;
(5) Alkylating agents, such as cyclophosphamide, etc.
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